Only for in vitro use
Ramoplanin is a glycolipodepsipeptide antibiotic produced from an Actinoplanes strain, deposited in the American Type Culture Collection as ATCC 33076. The antibiotic is produced as a complex of three components A1, A2 and A3 of which A2 is the most abundant. In addition, three other minor factors, termed A’1, A’2 and A’3 are present. Ramoplanin is a cyclic peptide formed from sixteen amino acids and a D-mannosyl unit and differs in the nature of the di-unsatured fatty acid chain (R). The antibiotic is bactericidal for a variety of gram-positive bacteria and it does not show cross resistance with other antibiotics in clinical use. Ramoplanin inhibits cell wall peptidoglycan biosynthesis without affecting other macromolecular syntheses. It is indicated also for the treatment of Clostridium difficile-associated disease (CDAD) where there is a very high medical need for more effective therapies.
Cavalleri B, Pagani H, Volpe G, Selva E, Parenti F. A-16686, a new antibiotic from Actinoplanes. I. Fermentation, isolation and preliminary physico-chemical characteristics. J Antibiot (Tokyo). 1984 Apr; 37(4):309-17. doi: 10.7164/antibiotics.37.309. PMID: 6547132.